More writing: mTORC1 promotes m6A mRNA methylation

Mol Cell. 2021 May 20;81(10):2057-2058. doi: 10.1016/j.molcel.2021.04.020.


Cho et al. (2021) and Villa et al. (2021) demonstrate that mTORC1 stimulates m6A mRNA methylation via WTAP expression and SAM synthesis. Increased mRNA methylation in turn promotes cell growth by enhancing mRNA degradation or translation.

Publication types

  • Comment

MeSH terms

  • Mechanistic Target of Rapamycin Complex 1 / genetics
  • Methylation
  • RNA Stability*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Writing*


  • RNA, Messenger
  • Mechanistic Target of Rapamycin Complex 1