More writing: mTORC1 promotes m6A mRNA methylation

Sunil Shetty; Michael N Hall

doi:10.1016/j.molcel.2021.04.020

More writing: mTORC1 promotes m⁶A mRNA methylation

Mol Cell. 2021 May 20;81(10):2057-2058. doi: 10.1016/j.molcel.2021.04.020.

Authors

Sunil Shetty¹, Michael N Hall²

Affiliations

¹ Biozentrum, University of Basel, Basel, Switzerland.
² Biozentrum, University of Basel, Basel, Switzerland. Electronic address: m.hall@unibas.ch.

PMID: 34019785
DOI: 10.1016/j.molcel.2021.04.020

Abstract

Cho et al. (2021) and Villa et al. (2021) demonstrate that mTORC1 stimulates m⁶A mRNA methylation via WTAP expression and SAM synthesis. Increased mRNA methylation in turn promotes cell growth by enhancing mRNA degradation or translation.

Publication types

Comment

MeSH terms

Mechanistic Target of Rapamycin Complex 1 / genetics
Methylation
RNA Stability*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Writing*

Substances

RNA, Messenger
Mechanistic Target of Rapamycin Complex 1