NMDARs in prefrontal cortex - Regulation of synaptic transmission and plasticity

Neuropharmacology. 2021 Jul 1;192:108614. doi: 10.1016/j.neuropharm.2021.108614. Epub 2021 May 20.


In this review we consider the various roles played by N-methyl-d-aspartate receptors (NMDARs) located on pyramidal neurones in medial prefrontal cortex (mPFC). We focus on recent data from our lab that has investigated how NMDARs contribute to ongoing synaptic transmission in a frequency dependent manner, the plasticity of NMDARs and how this impacts their contribution to synaptic transmission, and finally consider how NMDARs contribute to plasticity induced by synchronous activation of two separate inputs to mPFC.

Keywords: Hippocampus; Learning and memory; NMDA receptors; Nucleus reuniens; Prefrontal cortex; Synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Long-Term Potentiation / physiology*
  • Neuronal Plasticity / physiology*
  • Prefrontal Cortex / physiology*
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Synaptic Transmission / physiology*


  • Receptors, N-Methyl-D-Aspartate