Suggesting 7,8-dihydroxyflavone as a promising nutraceutical against CNS disorders

Neurochem Int. 2021 Sep;148:105068. doi: 10.1016/j.neuint.2021.105068. Epub 2021 May 20.

Abstract

7,8-dihydroxyflavone (DHF), a naturally-occurring plant-based flavone, is a high-affinity tyrosine kinase receptor B (TrkB) agonist and a bioactive molecule of therapeutic interest for neuronal survival, differentiation, synaptic plasticity and neurogenesis. In the family of neurotrophic factors, this small BDNF-mimetic molecule has attracted considerable attention due to its oral bioavailability and ability to cross the blood-brain barrier. Recent evidences have shed light on the neuroprotective role of this pleiotropic flavone against several neurological disorders, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, Huntington's disease, and other CNS disorders. DHF also elicits potent protective actions against toxins-induced insults to brain and neuronal cells. DHF shows promising anti-oxidant and anti-inflammatory properties in ameliorating the neurodegenerative processes affecting the CNS. This review provides an overview of the significant neuroprotective potentials of DHF and discusses how it exerts its multitudinous beneficial effects by modulating different pathways linked with the pathophysiology of CNS disorders, and thus proposes it to be a nutraceutical against a broad spectrum of neurological disorders.

Keywords: Anti-inflammatory; BDNF-TrkB; Neurodegenerative disorders; Neuroprotection.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / prevention & control
  • Dietary Supplements*
  • Flavones / therapeutic use*
  • Humans
  • Neurodegenerative Diseases / drug therapy
  • Neuroprotective Agents / therapeutic use*

Substances

  • 6,7-dihydroxyflavone
  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavones
  • Neuroprotective Agents