Antibiotic residues in wastewaters from sewage treatment plants and pharmaceutical industries: Occurrence, removal and environmental impacts

Abstract

Sewage treatment plants (STPs) and pharmaceutical manufactories (PMFs) are recognized as important reservoirs for aquatic pollution with antibiotics. Although the occurrence of multiple classes of antibiotics has been mostly reported for STPs and PMFs, knowledge on the effects of wastewater treatment processes on the removal of antibiotics is not well documented. In this study, wastewaters were collected from different treatment points of two STPs and two PMFs in eastern China. Thirty-seven antibiotics within the four classes of fluoroquinolones (FQs), macrolides (MACs), sulfonamides (SAs) and tetracyclines (TCs) were analyzed. Among the investigated antibiotics, 19-33 out of 37 target compounds were detected at least once in the STPs wastewaters ranging from low ng/L to approximately 12.7 μ/L. In the wastewater samples collected from PMFs, up to 34 antibiotics were present with detection frequencies up to 100%, showing generally higher concentrations (up to 19.0 μ/L) than those at the STPs. FQs and SAs were the dominant antibiotic families, which accounted for more than 90% of the total antibiotic concentration in the wastewaters. Moreover, the removal of antibiotics by anaerobic-anoxic-oxic (A²O), membrane bioreactor (MBR) and conventional activated sludge (CAS) systems was evaluated. The MBR system exhibited the best performance, mainly due to the processes of biodegradation and sorption during biological treatments. Notably, several SAs (SMP, SMZ) and FQs (CIN, ENO) antibiotics were consistently detected at concentration levels of μ/L in the effluent samples. The culturable antibiotic-resistance tests and risk assessment indicated that the antibiotic-contaminated effluents would facilitate the development of resistant bacteria and pose high toxicity to non-target organisms in the aquatic environment. Overall, the findings suggested an urgent need for improving the wastewater treatment technologies for simultaneous removal of different classes of antibiotics.

Keywords: Antibiotic residues; Aquatic environment; Ecological risks; Membrane bioreactor; Pharmaceutical wastewater; Sewage treatment plants.