Presence of epoxide hydrolase and glutathione S-transferase in human pulmonary alveolar macrophages

Eur J Clin Pharmacol. 1988;34(4):419-21. doi: 10.1007/BF00542447.


Pulmonary alveolar macrophages (PAMs) were obtained from 11 patients by bronchoalveolar lavage. Epoxide hydrolase and glutathione S-transferase in sonicated PAMs were measured using benzo(a)pyrene-4,5-oxide as the substrate. The activity of epoxide hydrolase was 0.24 +/- 0.10 nmol/min/mg protein (mean +/- SD), and of glutathione S-transferase 0.22 +/- 0.12 nmol/min/mg protein. There was a significant difference in enzyme activities in the PAMs from smokers and non-smokers. Epoxides may be metabolized in PAMs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epoxide Hydrolases / metabolism*
  • Female
  • Glutathione Transferase / metabolism*
  • Humans
  • Macrophages / enzymology*
  • Male
  • Middle Aged
  • Pulmonary Alveoli / cytology
  • Pulmonary Alveoli / enzymology*


  • Glutathione Transferase
  • Epoxide Hydrolases