Inflammation can increase hepcidin in HFE-hereditary hemochromatosis

Clin Case Rep. 2021 May 20;9(5):e04114. doi: 10.1002/ccr3.4114. eCollection 2021 May.

Abstract

We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.

Keywords: hemochromatosis; hepcidin; inflammation; iron overload.

Publication types

  • Case Reports