We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low hepcidin concentration can be upregulated by inflammation, probably via the JAK/STAT3 pathway.
Keywords: hemochromatosis; hepcidin; inflammation; iron overload.
© 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.