Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.
Keywords: PP1 nuclear targeting subunit (PNUTS); PP1 phosphatase; RNA polymerase II; Replication stress; WD repeat-containing protein 82 (WDR82); carboxy-terminal domain (CTD); transcription-replication conflicts.
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.