New link between the RNA polymerase II-CTD and replication stress

Mol Cell Oncol. 2021 Apr 18;8(3):1910008. doi: 10.1080/23723556.2021.1910008.

Abstract

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

Keywords: PP1 nuclear targeting subunit (PNUTS); PP1 phosphatase; RNA polymerase II; Replication stress; WD repeat-containing protein 82 (WDR82); carboxy-terminal domain (CTD); transcription-replication conflicts.

Grant support

This work was supported by funds from Norges Forskningsråd [275918], Helse Sør-Øst RHF [2014035, 2013017] and Kreftforeningen [3367910].