SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition

Cell Rep Med. 2021 May 18;2(5):100286. doi: 10.1016/j.xcrm.2021.100286.

Abstract

COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.

Publication types

  • News
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neutralizing / blood*
  • Antibodies, Neutralizing / immunology
  • Antibody Formation
  • COVID-19 / pathology
  • COVID-19 / virology
  • Epitopes, T-Lymphocyte / immunology
  • HLA Antigens / genetics
  • Humans
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / isolation & purification
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / immunology
  • Spike Glycoprotein, Coronavirus / metabolism
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism

Substances

  • Antibodies, Neutralizing
  • Epitopes, T-Lymphocyte
  • HLA Antigens
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2

Supplementary concepts

  • SARS-CoV-2 variants