Abstract
COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.
© 2021.
Publication types
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News
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Neutralizing / blood*
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Antibodies, Neutralizing / immunology
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Antibody Formation
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COVID-19 / pathology
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COVID-19 / virology
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Epitopes, T-Lymphocyte / immunology
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HLA Antigens / genetics
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Humans
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SARS-CoV-2 / immunology*
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SARS-CoV-2 / isolation & purification
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Spike Glycoprotein, Coronavirus / chemistry
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Spike Glycoprotein, Coronavirus / immunology
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Spike Glycoprotein, Coronavirus / metabolism
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
Substances
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Antibodies, Neutralizing
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Epitopes, T-Lymphocyte
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HLA Antigens
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2