LIM domain proteins in cell mechanobiology

Cytoskeleton (Hoboken). 2021 Jun;78(6):303-311. doi: 10.1002/cm.21677. Epub 2021 Jun 10.

Abstract

The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.

Keywords: LIM proteins; actin cytoskeleton; adherens junctions; focal adhesions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Actin Cytoskeleton* / metabolism
  • Actins / metabolism
  • Biophysics
  • Cell Communication
  • LIM Domain Proteins* / genetics
  • LIM Domain Proteins* / metabolism
  • Protein Binding

Substances

  • Actins
  • LIM Domain Proteins