Complete remission of stage IV erythrodermic mycosis fungoides with large cell transformation through combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation

Aaron J Frederiks; Katherine J Creeper; Dominic V Spagnolo; Paul Cannell; Dejan Radeski

doi:10.1111/ajd.13606

Complete remission of stage IV erythrodermic mycosis fungoides with large cell transformation through combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation

Australas J Dermatol. 2021 Aug;62(3):e400-e403. doi: 10.1111/ajd.13606. Epub 2021 May 24.

Authors

Aaron J Frederiks^{1

2}, Katherine J Creeper^{2

3

4

5}, Dominic V Spagnolo^{1

3}, Paul Cannell^{3

4}, Dejan Radeski^{1

3

4}

Affiliations

¹ School of Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
² Department of Haematology, Royal Perth Hospital, Perth, Western Australia, Australia.
³ PathWest Laboratory Medicine, Perth, Western Australia, Australia.
⁴ Department of Haematology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
⁵ Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

PMID: 34028795
DOI: 10.1111/ajd.13606

Abstract

We report the case of a 59-year-old woman with stage IV erythrodermic mycosis fungoides (MF) and large cell transformation who, despite failing multiple previous treatments, achieved complete remission through a combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation (alloSCT). Further studies are needed in focussing on this combined regimen in treating cutaneous T-cell lymphoma (CTCL) and its efficacy as a bridging regimen in facilitating successful alloSCT.

Keywords: allogeneic hematopoietic stem cell transplantation; large cell transformation; mycosis fungoides; pralatrexate; romidepsin.

Publication types

Case Reports

MeSH terms

Aminopterin / analogs & derivatives*
Aminopterin / therapeutic use
Antibiotics, Antineoplastic / therapeutic use*
Depsipeptides / therapeutic use*
Female
Hematopoietic Stem Cell Transplantation*
Humans
Middle Aged
Mycosis Fungoides / pathology
Mycosis Fungoides / therapy*
Remission Induction
Skin Neoplasms / pathology
Skin Neoplasms / therapy*
Treatment Outcome

Substances

10-propargyl-10-deazaaminopterin
Antibiotics, Antineoplastic
Depsipeptides
romidepsin
Aminopterin