Design concepts for DNA-encoded library synthesis

Bioorg Med Chem. 2021 Jul 1:41:116189. doi: 10.1016/j.bmc.2021.116189. Epub 2021 May 1.


An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade's worth of DEL-driven screening.

Keywords: DNA-Encoded Library; Medicinal Chemistry.

MeSH terms

  • Combinatorial Chemistry Techniques
  • DNA / chemistry*
  • DNA Replication
  • Drug Design*
  • Drug Discovery*
  • Gene Library*
  • Small Molecule Libraries*


  • Small Molecule Libraries
  • DNA