Mechanisms of Gβγ Release upon GPCR Activation

Trends Biochem Sci. 2021 Sep;46(9):703-704. doi: 10.1016/j.tibs.2021.05.002. Epub 2021 May 22.


Gβγ release is a key event in the transduction of GPCR signals. However, the molecular mechanisms of this process have been unclear. A recent report by Knight et al. provides important clues into the sequence of events that lead to the liberation of Gβγ upon G protein activation by GPCRs.

Keywords: G protein-coupled receptors; G proteins; GNAO1 disorder; cellular signaling; signal transduction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • GTP-Binding Protein beta Subunits* / genetics
  • GTP-Binding Protein beta Subunits* / metabolism
  • GTP-Binding Protein gamma Subunits* / genetics
  • GTP-Binding Protein gamma Subunits* / metabolism
  • GTP-Binding Proteins
  • Protein Processing, Post-Translational
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction


  • GTP-Binding Protein beta Subunits
  • GTP-Binding Protein gamma Subunits
  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins