Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity

Curr Med Chem. 2021 Oct 25;28(33):6915-6930. doi: 10.2174/0929867328666210525124707.

Abstract

Background: Lipopolysaccharide (LPS), a Gram-negative bacterial cell wall component, evokes intensive inflammatory responses in the human body. Naturally, inflammation is a part of the host immune response to an infection; nonetheless, an exaggerated response can lead to a series of pathophysiological consequences, collectively known as LPS toxicity or septic shock.

Objective: This review will explore the cellular and experimental investigations that mainly focus on Curcumin's therapeutic effects on the LPS-mediated inflammatory responses.

Method: A literature review of all relevant studies was performed.

Conclusion: Curcumin has been reported to exert anti-inflammatory properties by interfering with LPS-induced inflammatory pathways, including binding to cell surface receptors of LPS, NF-kB activation pathway, and inflammasome activation. Further clinical studies on the effect of Curcumin in reducing the pathophysiological consequences of LPS toxicity would substantiate the use of this molecule for future therapeutic approaches.

Keywords: Curcumin; cytokine; inflammation; interleukin.; lipopolysaccharide; septic shock; turmeric.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Curcumin* / pharmacology
  • Curcumin* / therapeutic use
  • Humans
  • Inflammasomes
  • Lipopolysaccharides* / toxicity
  • NF-kappa B

Substances

  • Anti-Inflammatory Agents
  • Inflammasomes
  • Lipopolysaccharides
  • NF-kappa B
  • Curcumin