The role of ligand endocytosis in notch signalling

doi:10.1111/boc.202100009

Review

. 2021 Oct;113(10):401-418.

doi: 10.1111/boc.202100009. Epub 2021 Jun 4.

The role of ligand endocytosis in notch signalling

Ekaterina Seib¹, Thomas Klein¹

Affiliations

PMID: 34038572
DOI: 10.1111/boc.202100009

Review

The role of ligand endocytosis in notch signalling

Ekaterina Seib et al. Biol Cell. 2021 Oct.

. 2021 Oct;113(10):401-418.

doi: 10.1111/boc.202100009. Epub 2021 Jun 4.

Authors

Ekaterina Seib¹, Thomas Klein¹

Affiliation

¹ Institute of Genetics, Heinrich-Heine-Universitaet Duesseldorf, Universitaetsstr. 1, Duesseldorf, 40225, Germany.

PMID: 34038572
DOI: 10.1111/boc.202100009

Abstract

The Notch signalling receptor is a mechanoreceptor that is activated by force. This force elicits a conformational change in Notch that results in the release of its intracellular domain into the cytosol by two consecutive proteolytic cleavages. In most cases, the force is generated by pulling of the ligands on the receptor upon their endocytosis. In this review, we summarise recent work that shed a more detailed light on the role of endocytosis during ligand-dependent Notch activation and discuss the role of ubiquitylation of the ligands during this process.

Keywords: DSL ligands; Delta; Notch pathway; Serrat; endocytosis.

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References

1. Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.
1. Banks, S.M., Cho, B., Eun, S.H., Lee, J.H., Windler, S.L., Xie, X., Bilder, D. and Fischer, J.A. (2011) The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS One 6, e18259.
1. Bardin, A. and Schweisguth, F. (2006) Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev. Cell 10, 245-255.
1. Barsi, J.C., Rajendra, R., Wu, J.I. and Artzt, K. (2005) Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech. Dev. 122, 1106-1117.
1. Berndt, N., Seib, E., Kim, S., Troost, T., Lyga, M., Langenbach, J., Haensch, S., Kalodimou, K., Delidakis, C. and Klein, T. (2017) Ubiquitylation-independent activation of Notch signalling by Delta. eLife 6, e27346.

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[1] Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.

[2] Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.

[3] Banks, S.M., Cho, B., Eun, S.H., Lee, J.H., Windler, S.L., Xie, X., Bilder, D. and Fischer, J.A. (2011) The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS One 6, e18259.

[4] Banks, S.M., Cho, B., Eun, S.H., Lee, J.H., Windler, S.L., Xie, X., Bilder, D. and Fischer, J.A. (2011) The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS One 6, e18259.

[5] Bardin, A. and Schweisguth, F. (2006) Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev. Cell 10, 245-255.

[6] Bardin, A. and Schweisguth, F. (2006) Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev. Cell 10, 245-255.

[7] Barsi, J.C., Rajendra, R., Wu, J.I. and Artzt, K. (2005) Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech. Dev. 122, 1106-1117.

[8] Barsi, J.C., Rajendra, R., Wu, J.I. and Artzt, K. (2005) Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. Mech. Dev. 122, 1106-1117.

[9] Berndt, N., Seib, E., Kim, S., Troost, T., Lyga, M., Langenbach, J., Haensch, S., Kalodimou, K., Delidakis, C. and Klein, T. (2017) Ubiquitylation-independent activation of Notch signalling by Delta. eLife 6, e27346.

[10] Berndt, N., Seib, E., Kim, S., Troost, T., Lyga, M., Langenbach, J., Haensch, S., Kalodimou, K., Delidakis, C. and Klein, T. (2017) Ubiquitylation-independent activation of Notch signalling by Delta. eLife 6, e27346.

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The role of ligand endocytosis in notch signalling

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The role of ligand endocytosis in notch signalling

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