A new diet supplement formulation containing cranberry extract for the treatment of feline idiopathic cystitis

Nat Prod Res. 2022 Jun;36(11):2884-2887. doi: 10.1080/14786419.2021.1925273. Epub 2021 May 27.


This study aimed to investigate whether cranberry extract could reduce lower urinary tract (LUT) and gastro-intestinal (GI) signs in feline idiopathic cystitis (FIC). Twenty-one client-owned cats were randomly allocated to two groups: a treated group (T, n = 10) receiving daily an oral nutritional supplement containing cranberry extract and a control group (C, n = 11). Owners were trained to recognise daily LUT and GI signs. Physical examination, urinalysis and bladder ultrasonography were performed at day 0 (T0), 15 (T15), 30 (T30), 60 (T60). Both groups showed an improvement for dysuria and periuria from T0 to T30 (p < 0.05), but only in cats of the T group, LUT signs disappeared at T60. A significant improvement in the T group was also observed for GI signs and bladder ultrasonography at T60 (p = 0.03). Urinalysis did not show any significant differences. This preliminary study suggests that cranberry could be effective in reducing LUT and GI signs in FIC.

Keywords: Cat; clinical pathology; clinical trial; cranberry; diet supplement; feline idiopathic cystitis.

Publication types

  • Randomized Controlled Trial, Veterinary

MeSH terms

  • Animals
  • Cats
  • Cystitis* / diagnosis
  • Cystitis* / drug therapy
  • Cystitis* / veterinary
  • Diet / veterinary
  • Dietary Supplements
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Vaccinium macrocarpon*


  • Plant Extracts