The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH): A Research Protocol

Vitor H F Oliveira; Kristine M Erlandson; Paul F Cook; Catherine Jankowski; Samantha MaWhinney; Sahera Dirajlal-Fargo; Leslie Knaub; Chao-Pin Hsiao; Christine Horvat Davey; Allison R Webel

doi:10.1097/JNC.0000000000000276

The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH): A Research Protocol

J Assoc Nurses AIDS Care. 2022 Mar-Apr;33(2):178-188. doi: 10.1097/JNC.0000000000000276.

Authors

Vitor H F Oliveira¹, Kristine M Erlandson, Paul F Cook, Catherine Jankowski, Samantha MaWhinney, Sahera Dirajlal-Fargo, Leslie Knaub, Chao-Pin Hsiao, Christine Horvat Davey, Allison R Webel

Affiliation

¹ Vitor H. F. Oliveira, PhD, is an Acting Instructor, University of Washington, School of Nursing, Seattle, Washington, USA. Kristine M. Erlandson, MD, MS, is an Associate Professor, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Paul F. Cook, PhD, is an Associate Professor, University of Colorado College of Nursing, Anschutz Medical Campus, Aurora, Colorado, USA. Catherine Jankowski, PhD, is an Associate Professor, University of Colorado College of Nursing, Anschutz Medical Campus, Aurora, Colorado, USA. Samantha MaWhinney, ScD, is a Professor, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Sahera Dirajlal-Fargo, DO, MS, is an Assistant Professor, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA. Leslie Knaub, MS, is a Senior Professional Research Assistant, University of Colorado Anschutz Medical Campus, Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA. Chao-Pin Hsiao, RN, PhD, FAAN, is an Assistant Professor, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Christine Horvat Davey, RN, PhD, is a Research Associate and Postdoctoral Fellow, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Allison R. Webel, RN, PhD, FAAN, is a Professor and Associate Dean for Research, University of Washington, School of Nursing, Seattle, Washington, USA.

Abstract

The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH), which incorporates an exercise and biobehavioral coaching intervention, has the following overall goals: (a) to determine whether high-intensity interval training (HIIT) mitigates physical function impairments, fatigue, and impairments in mitochondrial bioenergetics of older people living with HIV (PLWH) to a greater extent than continuous moderate exercise (CME); and (b) to determine whether a biobehavioral coaching and mobile health text messaging intervention after HIIT or CME can promote long-term adherence to physical activity. The HEALTH study is a randomized trial of 100 older PLWH (≥50 years of age) who self-report fatigue and have a sedentary lifestyle. Enrolled participants will be randomized to 16 weeks of supervised HIIT or CME training, followed by a 12-week maintenance phase, involving a mobile health coaching intervention. Outcomes of the HEALTH study will inform the development of scalable, effective exercise recommendations tailored to the unique needs of aging PLWH.

Trial registration: ClinicalTrials.gov NCT04550676.

Publication types

Clinical Trial Protocol
Research Support, N.I.H., Extramural

MeSH terms

Aged
Exercise
HIV Infections*
Habits
High-Intensity Interval Training*
Humans
Randomized Controlled Trials as Topic
Sedentary Behavior

Associated data

ClinicalTrials.gov/NCT04550676

Abstract

Publication types

MeSH terms

Associated data

Grants and funding