Single-cell RNA sequencing in pancreatic cancer

Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):451-452. doi: 10.1038/s41575-021-00471-z.


The application of single-cell RNA sequencing platforms has generated notable insights into the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing both the neoplastic compartment and the tumour microenvironment. In this Comment, we discuss the most pertinent findings gleaned from both mouse models and human PDAC samples, as well as future opportunities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinoma, Pancreatic Ductal / genetics*
  • Disease Models, Animal
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mice
  • Pancreatic Neoplasms / genetics*
  • Sequence Analysis, RNA / methods*
  • Sequence Analysis, RNA / trends
  • Tumor Microenvironment / physiology