Modeling of Activity-Induced Changes in Signal Propagation Speed of Mechano-Electrically Stimulated Nerve Fiber

Stud Health Technol Inform. 2021 May 27:281:93-97. doi: 10.3233/SHTI210127.

Abstract

One of the important questions in the research on neural coding is how the preceding axonal activity affects the signal propagation speed of the following one. We present an approach to solving this problem by introducing a multi-level spike count for activity quantification and fitting a family of linear regression models to the data. The best-achieved score is R2=0.89 and the comparison of different models indicates the importance of long and very short nerve fiber memory. Further studies are required to understand the complex axonal mechanisms responsible for the discovered phenomena.

Keywords: Microneurography; machine learning; neural coding; neuropathy; spike count.

MeSH terms

  • Action Potentials
  • Nerve Fibers*