Towards living guidelines on cardiorenal outcomes in diabetes: A pilot project of the Taskforce of the Guideline Workshop 2020

Diabetes Res Clin Pract. 2021 Jul:177:108870. doi: 10.1016/j.diabres.2021.108870. Epub 2021 May 24.


In June 2020, the Taskforce of the Guideline Workshop 2019 convened via teleconferencing to initiate a pilot project that demonstrates the various processes and considerations involved in developing high-quality, evidence-based clinical practice guidelines for the medical management of individuals with type 2 diabetes (T2D) and its associated comorbidities, including cardiovascular disease (CVD) and chronic kidney disease (CKD). The goal of the pilot project was to create evidence-based guidelines for use of sodium-glucose transport protein 2 inhibitors (SGLT2-I) when managing very high risk T2D patients, evidenced by the presence of both CVD and CKD. For this purpose the Taskforce represented a guideline panel and made use of synthesized evidence from an ongoing BMJ Rapid Recommendations project on SGLT2-I and GLP-1 receptor agonists. Results from the Taskforce pilot project demonstrated the value, feasibility and utility of using a step-wise approach to identifying and grading evidence and then developing actionable recommendations for utilizing SGLT2-I in this at-risk T2D population. This report describes the various steps involved in the process and explains how it can be utilized to rapidly develop recommendations in a format that is easy to use and can be quickly updated as new evidence becomes available, also within the emerging concept of living guidelines.

Keywords: Cardiovascular disease; Chronic kidney disease; GLP-1; Guidelines; MAGICapp; SGLT2-I; Type 2 diabetes.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / epidemiology
  • Humans
  • Hypoglycemic Agents
  • Pilot Projects
  • Practice Guidelines as Topic*
  • Sodium-Glucose Transport Proteins
  • Sodium-Glucose Transporter 2 Inhibitors


  • Hypoglycemic Agents
  • Sodium-Glucose Transport Proteins
  • Sodium-Glucose Transporter 2 Inhibitors