Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus

Sophia A Ederaine; Johanny Lopez Dominguez; Jamison A Harvey; Aaron R Mangold; Curtiss B Cook; Heidi Kosiorek; Matthew Buras; Kyle Coppola; Nina J Karlin

doi:10.2144/fsoa-2020-0150

Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus

Future Sci OA. 2021 Feb 10;7(5):FSO683. doi: 10.2144/fsoa-2020-0150.

Authors

Sophia A Ederaine¹, Johanny Lopez Dominguez¹, Jamison A Harvey², Aaron R Mangold², Curtiss B Cook³, Heidi Kosiorek⁴, Matthew Buras⁵, Kyle Coppola⁶, Nina J Karlin⁷

Affiliations

¹ Mayo Clinic Alix School of Medicine, Scottsdale, AZ 85259, USA.
² Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA.
³ Division of Endocrinology, Mayo Clinic, Scottsdale, AZ 85259, USA.
⁴ Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ 85259, USA.
⁵ Department of Cancer Quality Program, Mayo Clinic, Scottsdale, AZ 85259, USA.
⁶ Department of Information Technology, Mayo Clinic, Phoenix, AZ 85054, USA.
⁷ Division of Hematology & Medical Oncology, Mayo Clinic Cancer Center, Phoenix, AZ 85054, USA.

Abstract

Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control.

Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007-2017). Overall survival and recurrence-free survival were estimated using the Kaplan-Meier method. Hemoglobin A_1c (HbA_1c) and glucose level during the year following cancer diagnosis were compared using mixed models.

Results: HbA_1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004).

Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.

Keywords: cancer; diabetes; endocrinology; glycemic control; outcomes research; squamous cell carcinoma.