Effect of sex hormones on human voice physiology: from childhood to senescence

Hormones (Athens). 2021 Dec;20(4):691-696. doi: 10.1007/s42000-021-00298-y. Epub 2021 May 28.

Abstract

The aim of the present literature review is to describe the influence of sex hormones on the human voice in physiological conditions. As a secondary sexual organ, the larynx is affected by sex hormones and may change considerably over the lifespan. In the current review, sex hormone-related voice modifications occurring during childhood, puberty, the menstrual cycle, pregnancy and senescence are described. The roles of sex hormones (including gonadotropins, testosterone, estrogen, androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone-sulfate) underlying physiological voice changes are discussed, the main differences between males and females are explained and clinical implications are taken into account.

Keywords: Communication; Physiology; Sex hormones. Endocrinology; Voice.

Publication types

  • Review

MeSH terms

  • Androgens
  • Androstenedione
  • Dehydroepiandrosterone
  • Estrogens
  • Female
  • Gonadal Steroid Hormones* / physiology
  • Gonadotropins
  • Humans
  • Male
  • Pregnancy
  • Testosterone
  • Voice / physiology*

Substances

  • Androgens
  • Estrogens
  • Gonadal Steroid Hormones
  • Gonadotropins
  • Testosterone
  • Androstenedione
  • Dehydroepiandrosterone