Data from ENROLL-HD: Is the prevalence of juvenile and pediatric Huntington's disease overestimated?

Parkinsonism Relat Disord. 2021 Jul:88:1-2. doi: 10.1016/j.parkreldis.2021.05.012. Epub 2021 May 20.


Background: No study investigated the prevalence of pediatric Huntington's Disease.

Methods: Prevalence was analyzed in ENROLL-HD from participants and family trees.

Results: 50 compared with 7544 adult (0.66%) and 22 out of 16,124 family participants (0.14%) were pediatric.

Conclusions: The pediatric prevalence in the biggest HD study ranges unexpected low between 0.14 and 0.66%.

Keywords: Huntington's disease; Movement disorders; Paediatric neurology; Prevalence.

Publication types

  • Letter
  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Humans
  • Huntington Disease / epidemiology*
  • Male
  • Prevalence
  • Young Adult