Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

Leuk Res. 1988;12(6):523-7. doi: 10.1016/0145-2126(88)90120-8.

Abstract

Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-1-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Base Sequence*
  • Gene Amplification*
  • Humans
  • Karyotyping
  • Leukemia / genetics*
  • Male
  • Middle Aged
  • Proto-Oncogenes*
  • Sequence Homology, Nucleic Acid*