Iridium Complex-Catalyzed Transfer Hydrogenation of N-Heteroarenes and Tentative Asymmetric Synthesis

Lu Ouyang; Yanping Xia; Jianhua Liao; Rui Miao; Xiao Yang; Renshi Luo

doi:10.1021/acsomega.1c00868

Iridium Complex-Catalyzed Transfer Hydrogenation of N-Heteroarenes and Tentative Asymmetric Synthesis

ACS Omega. 2021 Apr 7;6(15):10415-10427. doi: 10.1021/acsomega.1c00868. eCollection 2021 Apr 20.

Authors

Lu Ouyang¹, Yanping Xia¹, Jianhua Liao¹, Rui Miao¹, Xiao Yang¹, Renshi Luo¹

Affiliation

¹ School of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi, P. R. China.

Abstract

An iridium-catalyzed transfer hydrogenation of N-heteroarenes to access a series of substituted 1,2,3,4-tetrahydroquinoline derivatives in excellent yields is disclosed. This transformation is distinguished with water-soluble and air-stable iridium complexes as the catalyst, formic acid as the hydrogen source, mild reaction conditions, and broad functional group compatibility. Most importantly, a tentative chiral N,N-chelated Cp*Ir(III) complex-catalyzed enantioselective transfer hydrogenation is also presented, affording chiral products in excellent yields and good enantioselectivities.