Omega-3 supplementation and heart failure: A meta-analysis of 12 trials including 81,364 participants

Mahmoud Barbarawi; Harini Lakshman; Owais Barbarawi; Ahmad Alabdouh; Mariam Al Kasasbeh; Luc Djousse; JoAnn E Manson

doi:10.1016/j.cct.2021.106458

Omega-3 supplementation and heart failure: A meta-analysis of 12 trials including 81,364 participants

Contemp Clin Trials. 2021 Aug:107:106458. doi: 10.1016/j.cct.2021.106458. Epub 2021 May 28.

Authors

Mahmoud Barbarawi¹, Harini Lakshman², Owais Barbarawi³, Ahmad Alabdouh⁴, Mariam Al Kasasbeh⁵, Luc Djousse⁶, JoAnn E Manson⁷

Affiliations

¹ Department of Cardiology, University of Connecticut, Farmington, CT, USA. Electronic address: Barbarawi@uchc.edu.
² Department of Internal Medicine, Hurley Medical Center/Michigan State University, Flint, MI, USA.
³ Department of Internal Medicine, Mutah University, Al-Karak, Jordan.
⁴ Department of Internal Medicine, Saint Agnes Hospital, Baltimore, MD, USA.
⁵ Department of Health Administration, Western Connecticut State University, CT, USA.
⁶ Department of Medicine, Division of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
⁷ Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

PMID: 34058392
DOI: 10.1016/j.cct.2021.106458

Abstract

Heart failure (HF) remains a leading cause of hospitalization and mortality. Marine omega-3 fatty acid supplements (omega-3 s) have shown efficacy in decreasing sudden cardiac death and improving the left ventricle ejection fraction percent (LVEF%). In this review, we evaluated the effect of marine omega-3 fatty acid supplements (omega-3 s) on HF hospitalization, recurrent HF hospitalization, and cardiovascular mortality in patients with heart failure. We found that omega-3 supplementation did not reduce first HF hospitalization or cardiovascular mortality but did significantly reduce recurrent HF hospitalizations, as compared with placebo.

Keywords: Heart failure; Hospitalization; Omega-3 fatty acids.

Publication types

Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Dietary Supplements
Heart Failure* / drug therapy
Hospitalization
Humans
Stroke Volume
Ventricular Function, Left

Abstract

Publication types

MeSH terms

Grants and funding