Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma

Med Clin North Am. 2021 Jul;105(4):737-755. doi: 10.1016/j.mcna.2021.04.010.


The cutaneous lymphomas are malignancies of T-cell and B-cell lymphocytes in which the skin is the primary organ of involvement. The cutaneous T-cell lymphomas include variants that can mimic the presentation of common skin diseases or arthropod bites. Mycosis fungoides, the most common cutaneous T-cell lymphoma, usually presents as fixed asymptomatic patches or plaques in sun-protected areas. The cutaneous B-cell lymphomas have fewer variants that often present as papules or nodules that can mimic nonmelanoma skin cancers. Some therapies for cutaneous lymphoma have unique side effects such as central hypothyroidism, hyperlipidemia, and peripheral neuropathy.

Keywords: Cutaneous T-cell lymphoma; Cutaneous lymphoma; Lymphomatoid papulosis; Mycosis fungoides; Primary cutaneous CD30+ anaplastic lymphoma; Sézary syndrome.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Animals
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents, Immunological / adverse effects
  • Arthropods
  • Bexarotene / adverse effects
  • Bites and Stings / diagnosis
  • Brentuximab Vedotin / adverse effects
  • Diagnosis, Differential
  • Humans
  • Hyperlipidemias / chemically induced
  • Hypothyroidism / chemically induced
  • Lymphoma, Primary Cutaneous Anaplastic Large Cell / diagnosis
  • Lymphoma, T-Cell, Cutaneous / classification
  • Lymphoma, T-Cell, Cutaneous / diagnosis*
  • Lymphoma, T-Cell, Cutaneous / therapy*
  • Lymphomatoid Papulosis / diagnosis
  • Mycosis Fungoides / diagnosis
  • Peripheral Nervous System Diseases / chemically induced
  • Prognosis
  • Sezary Syndrome / diagnosis
  • Skin Diseases / diagnosis*
  • Skin Diseases / pathology
  • Skin Neoplasms / pathology*


  • Antineoplastic Agents
  • Antineoplastic Agents, Immunological
  • Brentuximab Vedotin
  • Bexarotene