Salvage surgery for residual or recurrent laryngeal squamous cell carcinoma after (Chemo)radiotherapy: Oncological outcomes and prognostic factors

Eur J Surg Oncol. 2021 Nov;47(11):2711-2721. doi: 10.1016/j.ejso.2021.05.035. Epub 2021 May 26.


Nonsurgical primary treatment of early and advanced laryngeal squamous cell carcinoma, employing radiotherapy with or without chemotherapy, is considered a standard of care in many centers throughout the world. When patients have persistent or recurrent disease after non-surgical treatment, salvage surgery is frequently the only remaining potentially curative treatment. Depending on the extent of the residual/recurrent disease, different surgical salvage options are at the surgeon's disposal. In selected cases with limited local disease, salvage transoral laser microsurgery, transoral robotic surgery and open partial laryngectomies can be employed to achieve cure while preserving laryngeal function. For more advanced cases total laryngectomy is necessary. Identifying situations with unacceptable results from surgical salvage may guide future therapies.

Keywords: Conservation surgery; Laryngeal carcinoma; Oncological outcomes; Prognostic factors; Salvage surgery; Squamous cell carcinoma; Total laryngectomy; Transoral laser microsurgery.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell / surgery*
  • Carcinoma, Squamous Cell / therapy
  • Chemoradiotherapy*
  • Humans
  • Laryngeal Neoplasms / surgery*
  • Laryngeal Neoplasms / therapy
  • Laryngectomy
  • Laser Therapy
  • Microsurgery
  • Neoplasm Recurrence, Local / surgery*
  • Neoplasm Recurrence, Local / therapy
  • Neoplasm, Residual / surgery*
  • Neoplasm, Residual / therapy
  • Prognosis
  • Robotic Surgical Procedures
  • Salvage Therapy / methods*