Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains

Nutrients. 2021 May 1;13(5):1534. doi: 10.3390/nu13051534.


The gastrointestinal (GI) side-effects of dietary fibers are recognized, but less is known about their effects on non-GI symptoms. We assessed non-GI symptoms in a trial of the LDL-cholesterol lowering effect of oat β-glucan (OBG). Participants (n = 207) with borderline high LDL-cholesterol were randomized to an OBG (1 g OBG, n = 104, n = 96 analyzed) or Control (n = 103, n = 95 analyzed) beverage 3-times daily for 4 weeks. At screening, baseline, 2 weeks and 4 weeks participants rated the severity of 16 non-GI symptoms as none, mild, moderate or severe. The occurrence and severity (more or less severe than pre-treatment) were compared using chi-squared and Fisher's exact test, respectively. During OBG treatment, the occurrence of exhaustion and fatigue decreased versus baseline (p < 0.05). The severity of headache (2 weeks, p = 0.032), anxiety (2 weeks p = 0.059) and feeling cold (4 weeks, p = 0.040) were less on OBG than Control. The severity of fatigue and hot flashes at 4 weeks, limb/joint pain at 2 weeks and difficulty concentrating at both times decreased on OBG versus baseline. High serum c-reactive-protein and changes in c-reactive-protein, oxidized-LDL, and GI-symptom severity were associated with the occurrence and severity of several non-GI symptoms. These data provide preliminary, hypothesis-generating evidence that OBG may reduce several non-GI symptoms in healthy adults.

Keywords: beta-glucan; dietary fiber; gastrointestinal tract; humans; musculo-skeletal system; oatmeal; oats; randomized clinical trial; symptoms.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Affect / drug effects*
  • Aged
  • Anxiety / therapy
  • C-Reactive Protein / analysis
  • Chi-Square Distribution
  • Cholesterol, LDL / blood
  • Dietary Fiber / pharmacology*
  • Double-Blind Method
  • Eating / psychology*
  • Fasting / blood
  • Fatigue / therapy
  • Female
  • Gastrointestinal Tract / drug effects
  • Headache / therapy
  • Healthy Volunteers
  • Humans
  • Male
  • Middle Aged
  • Musculoskeletal Pain / therapy
  • Nutritional Physiological Phenomena
  • Severity of Illness Index
  • Young Adult
  • beta-Glucans / pharmacology*


  • Cholesterol, LDL
  • Dietary Fiber
  • beta-Glucans
  • beta-glucan, (1-3)(1-4)-
  • C-Reactive Protein

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