Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

Int J Mol Sci. 2021 May 7;22(9):4983. doi: 10.3390/ijms22094983.


Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.

Keywords: biodegradable nanoparticles; clinical trials; microneedles; psoriasis; psoriasis versus atopic dermatitis; skin inflammatory diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Humans
  • Models, Biological
  • Nanomedicine*
  • Nanotechnology
  • Psoriasis / etiology*
  • Psoriasis / pathology
  • Psoriasis / physiopathology
  • Psoriasis / therapy*