Antioxidant and Cytoprotective Properties of Plant Extract from Dry Flowers as Functional Dyes for Cosmetic Products

Molecules. 2021 May 10;26(9):2809. doi: 10.3390/molecules26092809.

Abstract

Nowadays, natural dyes are expected by the cosmetic and food industries. In contrast to synthetic dyes, colorants derived from natural sources are more environmentally friendly and safer for human health. In this work, plant extracts from Gomphrena globasa L., Clitoria ternatea L., Carthamus tinctorius L., Punica granatum L. and Papaver rhoeas L. as the natural and functional dyes for the cosmetics industry were assessed. Cytotoxicity on keratinocyte and fibroblast cell lines was determined as well as antioxidant and anti-aging properties by determining their ability to inhibit the activity of collagenase and elastase enzymes. In addition, the composition of the extracts was determined. The obtained extracts were also applied in face cream formulation and color analyses were performed. It has been shown that the obtained extracts were characterized by no cytotoxicity and a high antioxidant potential. The extracts also show strong ability to inhibit the activity of collagenase and moderate ability to inhibit elastase and provide effective and long-lasting hydration after their application on the skin. Application analyses showed that the extracts of P. rhoeas L., C. ternatea L. and C. tinctorius L. can be used as effective cosmetic dyes that allow for attainment of an intense and stable color during the storage of the product. The extracts of P. granatum L. and G. globasa L., despite their beneficial effects as active ingredients, did not work effectively as cosmetic dyes, because cosmetic emulsions with these extracts did not differ significantly in color from emulsions without the extract.

Keywords: biologically active dyes; cosmetics; natural dyes; plant extracts.

MeSH terms

  • Antioxidants / pharmacology*
  • Benzothiazoles / chemistry
  • Biphenyl Compounds / chemistry
  • Cell Death / drug effects
  • Collagenases / metabolism
  • Color
  • Coloring Agents / pharmacology*
  • Cosmetics / pharmacology*
  • Cytoprotection* / drug effects
  • Desiccation*
  • Flowers / chemistry*
  • HaCaT Cells
  • Humans
  • Kinetics
  • Matrix Metalloproteinase Inhibitors / pharmacology
  • Oxazines / metabolism
  • Pancreatic Elastase / antagonists & inhibitors
  • Pancreatic Elastase / metabolism
  • Picrates / chemistry
  • Plant Extracts / pharmacology*
  • Plants / chemistry
  • Skin Cream / pharmacology
  • Sulfonic Acids / chemistry
  • Ultraviolet Rays
  • Water Loss, Insensible / drug effects
  • Xanthenes / metabolism

Substances

  • Antioxidants
  • Benzothiazoles
  • Biphenyl Compounds
  • Coloring Agents
  • Cosmetics
  • Matrix Metalloproteinase Inhibitors
  • Oxazines
  • Picrates
  • Plant Extracts
  • Sulfonic Acids
  • Xanthenes
  • resazurin
  • 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
  • 1,1-diphenyl-2-picrylhydrazyl
  • Pancreatic Elastase
  • Collagenases