MicroRNA as a Prognostic and Diagnostic Marker in T-Cell Acute Lymphoblastic Leukemia

Int J Mol Sci. 2021 May 18;22(10):5317. doi: 10.3390/ijms22105317.


T cell acute lymphoblastic leukemia (T-ALL) is a biologically and genetically heterogeneous disease with a poor prognosis overall and several subtypes. The neoplastic transformation takes place through the accumulation of numerous genetic and epigenetic abnormalities. There are only a few prognostic factors in comparison to B cell precursor acute lymphoblastic leukemia, which is characterized by a lower variability and more homogeneous course. The microarray and next-generation sequencing (NGS) technologies exploring the coding and non-coding part of the genome allow us to reveal the complexity of the genomic and transcriptomic background of T-ALL. miRNAs are a class of non-coding RNAs that are involved in the regulation of cellular functions: cell proliferations, apoptosis, migrations, and many other processes. No miRNA has become a significant prognostic and diagnostic factor in T-ALL to date; therefore, this topic of investigation is extremely important, and T-ALL is the subject of intensive research among scientists. The altered expression of many genes in T-ALL might also be caused by wide miRNA dysregulation. The following review focuses on summarizing and characterizing the microRNAs of pediatric patients with T-ALL diagnosis and their potential future use as predictive factors.

Keywords: T-ALL; T-ALL markers; diagnostic marker; microRNA; predictive marker.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / classification
  • Biomarkers, Tumor / genetics*
  • Biomarkers, Tumor / metabolism
  • Child
  • Drug Resistance, Neoplasm / genetics
  • Gene Expression Profiling
  • Humans
  • MicroRNAs / classification
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Prognosis
  • Treatment Failure


  • Biomarkers, Tumor
  • MicroRNAs