Glucagon in treatment of hypoglycemia - novelties

Vnitr Lek. 2021 Spring;67(2):103-108.

Abstract

Glucagon is actually used in the treatment of severe hypoglycemia. Due to technological difficulties with stability in solution, glucagon in currently available preparations was contained in a form of powder, which needs to be first dissolved in the water before application. This particular administration of glucagon was associated with a certain delay and several mistakes that decreased real amount of glucagon injected in the body. Currently two new formulas of glucagon appeared on the market - first as a stable liquid solution, second as a powder for nasal administration. This article summarizes currently available information about these preparations.

Keywords: diabetes; glucagon; hypoglycemia; therapy; type 2 diabetes.

MeSH terms

  • Administration, Intranasal
  • Blood Glucose
  • Diabetes Mellitus, Type 1*
  • Glucagon / therapeutic use*
  • Humans
  • Hypoglycemia* / chemically induced
  • Hypoglycemia* / drug therapy
  • Insulin / therapeutic use

Substances

  • Blood Glucose
  • Insulin
  • Glucagon