Abstract
The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, a clinically used drug, acetazolamide (a specific inhibitor of carbonic anhydrase, CA, EC 4.2.1.1), is used to treat high-altitude pulmonary oedema (HAPE), showing a high degree of clinical similarities with the pulmonary disease caused by Covid-19. In this context, this preliminary study aims to provide insights into some factors affecting the Covid-19 patients, such as hypoxaemia, hypoxia as well as the blood CA activity. We hypothesise that patients with Covid-19 problems could show a dysregulated acid-base status influenced by CA activity. These preliminary results suggest that the use of CA inhibitors as a pharmacological treatment for Covid-19 may be beneficial.
Keywords:
CO2; Covid-19; carbonic anhydrase; high-altitude pulmonary oedema; hypoxia.
MeSH terms
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Acetazolamide / therapeutic use*
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Acid-Base Equilibrium / drug effects
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Altitude Sickness / blood
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Altitude Sickness / drug therapy
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Anticonvulsants / therapeutic use
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Antiviral Agents / therapeutic use*
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Bicarbonates / blood
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COVID-19 / blood
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COVID-19 / diagnostic imaging
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COVID-19 / virology
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COVID-19 Drug Treatment*
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Carbon Dioxide / blood
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Carbonic Anhydrase Inhibitors / therapeutic use*
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Carbonic Anhydrases / blood*
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Cough / blood
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Cough / drug therapy
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Cough / pathology
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Cough / virology
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Drug Repositioning
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Dyspnea / blood
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Dyspnea / drug therapy
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Dyspnea / pathology
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Dyspnea / virology
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Fever / blood
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Fever / drug therapy
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Fever / pathology
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Fever / virology
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Humans
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Hydrogen-Ion Concentration
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Hypertension, Pulmonary / blood
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Hypertension, Pulmonary / drug therapy
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Hypoxia / blood
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Hypoxia / drug therapy
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Hypoxia / pathology
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Hypoxia / virology
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Oximetry
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Research Design
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SARS-CoV-2 / pathogenicity
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SARS-CoV-2 / physiology
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Severity of Illness Index
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Tomography, X-Ray Computed
Substances
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Anticonvulsants
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Antiviral Agents
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Bicarbonates
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Carbonic Anhydrase Inhibitors
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Carbon Dioxide
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Carbonic Anhydrases
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Acetazolamide
Supplementary concepts
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Pulmonary edema of mountaineers