Cardiovascular malformations and organic solvent exposure during pregnancy in Finland

Am J Ind Med. 1988;14(1):1-8. doi: 10.1002/ajim.4700140102.


In order to investigate the possible association between cardiovascular malformations and maternal exposure to organic solvents during the first trimester of pregnancy, 569 cases and 1,052 controls were retrospectively studied. The cases represented all infants with diagnosed cardiovascular malformations born in Finland in 1982-1984, and the controls were randomly selected from all normal births in the country during the same period. All mothers were interviewed approximately 3 months after delivery by a midwife using a structured questionnaire. Exposures to organic solvents at work during the first trimester of pregnancy were slightly more prevalent among the mothers of affected infants (10.4%) than among those of controls (7.8%). Logistic regression analysis of exposure to organic solvents showed an adjusted relative odds ratio of 1.3 (95% confidence interval, 0.8-2.2). In the analysis of ventricular septal defect, exposure to organic solvents showed an adjusted relative odds ratio of 1.5 (95% confidence interval, 1.0-3.7).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Environmental Exposure
  • Female
  • Finland
  • Heart Defects, Congenital / chemically induced*
  • Heart Defects, Congenital / epidemiology
  • Heart Septal Defects, Ventricular / chemically induced
  • Heart Septal Defects, Ventricular / epidemiology
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Trimester, First
  • Regression Analysis
  • Retrospective Studies
  • Solvents / adverse effects*


  • Solvents