A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Patrice D Cani; Claude Knauf

doi:10.1016/j.cmet.2021.05.004

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Cell Metab. 2021 Jun 1;33(6):1073-1075. doi: 10.1016/j.cmet.2021.05.004.

Authors

Patrice D Cani¹, Claude Knauf²

Affiliations

¹ UCLouvain, Université Catholique de Louvain, WELBIO Walloon Excellence in Life Sciences and BIOtechnology, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium; International Research Project (IRP), European Lab "NeuroMicrobiota", Brussels/Toulouse, France and Belgium. Electronic address: patrice.cani@uclouvain.be.
² International Research Project (IRP), European Lab "NeuroMicrobiota", Brussels/Toulouse, France and Belgium; Université Paul Sabatier, Toulouse III, INSERM U1220, Institut de Recherche en Santé Digestive (IRSD), CHU Purpan, Place du Docteur Baylac, CS 60039, 31024 Toulouse Cedex 3, France.

PMID: 34077715
DOI: 10.1016/j.cmet.2021.05.004

Abstract

Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9) secreted by A. muciniphila that stimulates GLP-1 secretion, thereby adding new insight to the biomolecule era to treat metabolic diseases.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Akkermansia
Glucagon-Like Peptide 1*
Humans
Membrane Proteins
Metabolic Diseases*
Transcription Factors

Substances

Membrane Proteins
Transcription Factors
Glucagon-Like Peptide 1