Pathologic localization of Tamm-Horsfall protein in interstitial deposits in renal disease

Lab Invest. 1978 Jan;38(1):52-7.


Interstitial periodic acid-Schiff positive deposits of amorphous or fibrillar material were observed in 32% of kidneys with a variety of tubulointerstitial diseases, including medullary cystic disease (60%), chronic pyelonephritis (20%), and hydronephrosis (33%). Immunofluorescent staining for Tamm-Horsfall protein showed interstitial localization of this protein which was identical in distribution, shape, size, and fine detail with the periodic acid-Schiff positive deposits. The deposits appeared to originate from disrupted tubules and were sometimes surrounded by inflammatory infiltrate. The intrarenal localization of Tamm-Horsfall protein outside of distal tubules in pathologic states indicates that this protein may have a role in the pathogenesis of renal disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Fluorescent Antibody Technique
  • Glomerulonephritis / metabolism
  • Glycoproteins / metabolism*
  • Histological Techniques
  • Humans
  • Hydronephrosis / metabolism
  • Immunosorbent Techniques
  • Kidney / metabolism*
  • Kidney Diseases / metabolism*
  • Kidney Diseases, Cystic / metabolism
  • Kidney Tubules / metabolism
  • Nephritis, Interstitial / metabolism
  • Periodic Acid-Schiff Reaction
  • Polycystic Kidney Diseases / metabolism
  • Pyelonephritis / metabolism
  • Retrospective Studies


  • Glycoproteins