Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma

Roy Jung; Harish P Janardhan; Karen Dresser; Jennifer L Cotton; Lloyd Hutchinson; Junhao Mao; Chinmay M Trivedi

doi:10.1161/ATVBAHA.121.316300

Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma

Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2233-2235. doi: 10.1161/ATVBAHA.121.316300. Epub 2021 Jun 3.

Authors

Roy Jung^#^{1

2}, Harish P Janardhan^#^{1

2}, Karen Dresser³, Jennifer L Cotton^{4

5}, Lloyd Hutchinson³, Junhao Mao^{4

5}, Chinmay M Trivedi^{1

2

4

5}

Affiliations

¹ Division of Cardiovascular Medicine (R.J., H.P.J., C.M.T.), University of Massachusetts Medical School, Worcester.
² Department of Medicine (R.J., H.P.J., C.M.T.), University of Massachusetts Medical School, Worcester.
³ Department of Pathology (K.D., L.H.), University of Massachusetts Medical School, Worcester.
⁴ Department of Molecular, Cell, and Cancer Biology (J.L.C., J.M., C.M.T.), University of Massachusetts Medical School, Worcester.
⁵ Li-Weibo Institute for Rare Diseases Research (J.L.C., J.M., C.M.T.), University of Massachusetts Medical School, Worcester.

^# Contributed equally.

No abstract available

Keywords: heart neoplasms; morbidity; neoplasms; sarcoma; vascular diseases.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Antigens, CD / genetics
Antigens, CD / metabolism
Cadherins / genetics
Cadherins / metabolism
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism*
Cell Transformation, Neoplastic / pathology
Endothelial Cells / metabolism*
Endothelial Cells / pathology
Gene Expression Regulation, Neoplastic
Hemangioendothelioma, Epithelioid / genetics
Hemangioendothelioma, Epithelioid / metabolism*
Hemangioendothelioma, Epithelioid / pathology
Humans
Mice, Transgenic
Signal Transduction
Transcription Factors / genetics
Transcription Factors / metabolism
Vascular Neoplasms / genetics
Vascular Neoplasms / metabolism*
Vascular Neoplasms / pathology
YAP-Signaling Proteins

Substances

Adaptor Proteins, Signal Transducing
Antigens, CD
Cadherins
Transcription Factors
YAP-Signaling Proteins
YAP1 protein, human
Yap1 protein, mouse
cadherin 5

Publication types

MeSH terms

Substances

Grants and funding