Epstein-Barr virus positive diffuse large B-cell lymphoma transformed into angioimmunoblastic T-cell lymphoma after treatment

Chaoyu Wang; Yi Gong; Qingming Jiang; Xiping Liang; Rui Chen

doi:10.1002/ccr3.4083

Epstein-Barr virus positive diffuse large B-cell lymphoma transformed into angioimmunoblastic T-cell lymphoma after treatment

Clin Case Rep. 2021 May 5;9(5):e04083. doi: 10.1002/ccr3.4083. eCollection 2021 May.

Authors

Chaoyu Wang¹, Yi Gong¹, Qingming Jiang², Xiping Liang¹, Rui Chen²

Affiliations

¹ Department of Hematology-Oncology Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Chongqing China.
² Department of Pathology Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer Hospital Chongqing China.

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is the subtype of mature T-cell non-Hodgkin lymphoma. Compared with diffuse large B-cell lymphoma (DLBCL), AITL patients are frequently accompanied with Epstein-Barr virus (EBV) infection. To date, there is no report on the subsequent development of AITL in patients with EBV-positive DLBCL. We performed a rare case of EBV-positive AITL developing one year after initial diagnosis of EBV-positive DLBCL. The patient showed poor response to the chemotherapy regimen, and poor survival.

Keywords: Epstein–Barr virus; angioimmunoblastic T‐cell lymphoma; diffuse large B‐cell lymphoma.

Publication types

Case Reports