Sweet Dre-ams about intersectional genetics

Cell Stem Cell. 2021 Jun 3;28(6):989-990. doi: 10.1016/j.stem.2021.05.005.


Specific cell targeting with one site-specific recombinase is challenging. In this issue of Cell Stem Cell, Han et al. (2021) released a collection of Dre drivers and demonstrate how two recombinases can be combined to improve the cell specificity of lineage tracing and gene inactivation in mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Base Sequence
  • Cell Movement
  • Integrases* / metabolism
  • Mice
  • Recombinases* / genetics
  • Recombinases* / metabolism


  • Recombinases
  • Integrases