Charting a shared epigenetic pathway to CD8 + T cell dysfunction in infection and cancer

Mol Cell. 2021 Jun 3;81(11):2272-2274. doi: 10.1016/j.molcel.2021.05.020.


Pritykin et al. (2021) establish a comprehensive chromatin atlas of CD8+ T cell dysfunction in chronic viral infection and cancer via analysis of bulk and single-cell ATAC-seq datasets across immune challenges. These results unify the classification scheme and molecular programs driving CD8+ T cell dysfunction across disease settings and will facilitate basic discovery and translational efforts in T cell immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • CD8-Positive T-Lymphocytes*
  • Chromatin
  • Epigenesis, Genetic
  • Epigenomics
  • Humans
  • Neoplasms* / genetics


  • Chromatin