Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis

Li Chen; Jingjing Liu; Guibin Mei; Huimin Chen; Shufen Peng; Ying Zhao; Ping Yao; Yuhan Tang

doi:10.1016/j.fct.2021.112314

Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis

Food Chem Toxicol. 2021 Aug:154:112314. doi: 10.1016/j.fct.2021.112314. Epub 2021 Jun 2.

Authors

Li Chen¹, Jingjing Liu¹, Guibin Mei¹, Huimin Chen¹, Shufen Peng¹, Ying Zhao¹, Ping Yao¹, Yuhan Tang²

Affiliations

¹ Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Wuhan, 430030, China; Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
² Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Wuhan, 430030, China; Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: tyh043@126.com.

PMID: 34087406
DOI: 10.1016/j.fct.2021.112314

Abstract

Quercetin, a polyphenol widely present in the plant kingdom, has received great interest due to pleiotropic effects. As evidenced by animal and cellular studies, quercetin exerts hepatoprotection against non-alcoholic fatty liver disease (NAFLD), particularly in hepatic steatosis and hepatitis. Mechanically, various hypotheses of such protective effects have been actively proposed, including improving fatty acid metabolism, anti-inflammation, anti-oxidant, modulating gut microbiota and bile acid, etc. Here, the role of quercetin in NAFLD was summarized. With a particular focus on molecular mechanism, we comprehensively discussed the pathways of quercetin on NAFLD based on the analysis from Gene Expression Omnibus (GEO) database and experimental evidence.

Keywords: GEO database; Hepatoprotection; NAFLD; Quercetin.

Publication types

Review

MeSH terms

Animals
Bile Acids and Salts / metabolism
Computational Biology / methods*
Gastrointestinal Microbiome / drug effects
Humans
Lipid Metabolism / drug effects
Non-alcoholic Fatty Liver Disease / prevention & control*
Quercetin / pharmacology*

Substances

Bile Acids and Salts
Quercetin