Leveraging the Electronic Health Record to Address the COVID-19 Pandemic

Mayo Clin Proc. 2021 Jun;96(6):1592-1608. doi: 10.1016/j.mayocp.2021.04.008. Epub 2021 Apr 21.


The coronavirus disease 2019 (COVID-19) pandemic continues its global spread. Coordinated effort on a vast scale is required to halt its progression and to save lives. Electronic health record (EHR) data are a valuable resource to mitigate the COVID-19 pandemic. We review how the EHR could be used for disease surveillance and contact tracing. When linked to "omics" data, the EHR could facilitate identification of genetic susceptibility variants, leading to insights into risk factors, disease complications, and drug repurposing. Real-time monitoring of patients could enable early detection of potential complications, informing appropriate interventions and therapy. We reviewed relevant articles from PubMed, MEDLINE, and Google Scholar searches as well as preprint servers, given the rapidly evolving understanding of the COVID-19 pandemic.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • COVID-19 / diagnosis
  • COVID-19 / epidemiology*
  • COVID-19 / prevention & control
  • Contact Tracing / methods
  • Drug Repositioning
  • Electronic Health Records*
  • Epidemiological Monitoring
  • Humans
  • SARS-CoV-2 / genetics