Poor sulphoxidation ability in patients with food sensitivity

BMJ. 1988 Jul 9;297(6641):105-7. doi: 10.1136/bmj.297.6641.105.

Abstract

Patients with well defined reactions to foods were examined for their ability to carry out both sulphur and carbon oxidation reactions by using carbocisteine and debrisoquine as probe compounds. The proportion of poor sulphoxidisers (58 of 74) was significantly greater than that of a previously determined normal control population (67 of 200; p less than 0.005). The proportion of poor carbon oxidisers was not significantly different from the controls. Metabolic defects may play a part in the pathogenesis of adverse reactions to foods.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carbocysteine / metabolism
  • Carbocysteine / urine
  • Carbon / metabolism*
  • Debrisoquin / analogs & derivatives
  • Debrisoquin / metabolism
  • Debrisoquin / urine
  • Female
  • Food Hypersensitivity / metabolism*
  • Food Hypersensitivity / urine
  • Humans
  • Male
  • Middle Aged
  • Sulfur / metabolism*
  • Sulfur / urine

Substances

  • 4-hydroxydebrisoquin
  • Sulfur
  • Carbocysteine
  • Carbon
  • Debrisoquin