Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide

Int J Biol Macromol. 2021 Jul 31;183:2337-2353. doi: 10.1016/j.ijbiomac.2021.05.213. Epub 2021 Jun 6.

Abstract

Angelica sinensis polysaccharide (ASP) is one of the main active components of Angelica sinensis (AS) that is widely used in traditional Chinese medicine. ASP is water-soluble polysaccharides, and it is mainly composed of glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl) and galacturonic acid (GalUA). The extraction methods of ASP include hot water extraction and ultrasonic wave extraction, and different extraction methods can affect the yield of ASP. ASP has a variety of pharmacological activities, including hematopoietic activity, promoting immunity, antitumor, anti-inflammatory, antioxidant, anti-aging, anti-virus, liver protection, and so on. As a kind of natural polysaccharide, ASP has potential application as drug carriers. This review provides a comprehensive summary of the latest extraction and purification methods of ASP, the strategies used for monosaccharide compositional analysis plus polysaccharide structural characterization, pharmacological activities and drug carrier applications, and it can provide a basis for further study on ASP.

Keywords: Angelica sinensis polysaccharide; Drug carrier; Extraction; Pharmacological activity; Purification; Structural properties.

Publication types

  • Review

MeSH terms

  • Angelica sinensis / chemistry*
  • Animals
  • Drug Carriers*
  • Humans
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Polysaccharides / chemistry*
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Structure-Activity Relationship

Substances

  • Drug Carriers
  • Plant Extracts
  • Polysaccharides