Application of a convolutional neural network for fully-automated detection of spike ripples in the scalp electroencephalogram

J Neurosci Methods. 2021 Aug 1;360:109239. doi: 10.1016/j.jneumeth.2021.109239. Epub 2021 Jun 4.


Background: A reliable biomarker to identify cortical tissue responsible for generating epileptic seizures is required to guide prognosis and treatment in epilepsy. Combined spike ripple events are a promising biomarker for epileptogenic tissue that currently require expert review for accurate identification. This expert review is time consuming and subjective, limiting reproducibility and high-throughput applications.

New method: To address this limitation, we develop a fully-automated method for spike ripple detection. The method consists of a convolutional neural network trained to compute the probability that a spectrogram image contains a spike ripple.

Results: We validate the proposed spike ripple detector on expert-labeled data and show that this detector accurately separates subjects with low and high seizure risks.

Comparison with existing method: The proposed method performs as well as existing methods that require manual validation of candidate spike ripple events. The introduction of a fully automated method reduces subjectivity and increases rigor and reproducibility of this epilepsy biomarker.

Conclusion: We introduce and validate a fully-automated spike ripple detector to support utilization of this epilepsy biomarker in clinical and translational work.

Keywords: EEG; convolutional neural network; high frequency oscillations; ripples.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Electroencephalography
  • Epilepsy*
  • Humans
  • Neural Networks, Computer
  • Reproducibility of Results
  • Scalp*