Modification of Metal-Organic Framework Nanoparticles Using Dental Pulp Mesenchymal Stem Cell Membranes to Target Oral Squamous Cell Carcinoma

Dabo Zhou; Yixin Chen; Wenhuan Bu; Lin Meng; Congcong Wang; Nianqiang Jin; Yumeng Chen; Chunxia Ren; Kai Zhang; Hongchen Sun

doi:10.1016/j.jcis.2021.05.126

Modification of Metal-Organic Framework Nanoparticles Using Dental Pulp Mesenchymal Stem Cell Membranes to Target Oral Squamous Cell Carcinoma

J Colloid Interface Sci. 2021 Nov:601:650-660. doi: 10.1016/j.jcis.2021.05.126. Epub 2021 May 24.

Authors

Dabo Zhou¹, Yixin Chen², Wenhuan Bu¹, Lin Meng², Congcong Wang², Nianqiang Jin¹, Yumeng Chen², Chunxia Ren², Kai Zhang³, Hongchen Sun⁴

Affiliations

¹ School and Hospital of Stomatology, China Medical University, 117 Nanjing North Street, Shenyang 110002, China.
² State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
³ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China. Electronic address: zk@jlu.edu.cn.
⁴ School and Hospital of Stomatology, China Medical University, 117 Nanjing North Street, Shenyang 110002, China. Electronic address: hcsun@jlu.edu.cn.

PMID: 34091312
DOI: 10.1016/j.jcis.2021.05.126

Abstract

Engineering a targetable nanoparticle to tumor cell is a challenge issue for clinical application. Our results demonstrated that the chemokine CXCL8 secreted by oral squamous cell carcinoma (OSCC) could act as a chemoattractant to attract dental pulp mesenchymal stem cell (DPSC), which expressed the CXCL8 binding receptor, CXCR2, to the OSCC. Therefore, to create OSCC targetable nanoparticles, we used DPSC membranes to modify nanoparticles of metal-organic framework nanoparticles (MOFs) resulting in a novel MOF@DPSCM nanoparticle. Interestingly, results from in vitro and in vivo experiments illustrated that MOF@DPSCM possessed specificity for the OSCC, and the MOF@DPSCM carried DOX (doxorubicin), MOF-DOX@DPSCM could induce CAL27 cell death in vitro and block CAL27 tumor growth in vivo. Our data suggest that this novel MOF-DOX@DPSCM nanoparticle is a potential targetable drug delivery system for the OSCC in the future clinical application.

Keywords: Dental pulp mesenchymal stem cell; Metal-organic framework; Oral squamous cell carcinoma; Targetable nanoparticles or chemotherapy.

MeSH terms

Carcinoma, Squamous Cell* / drug therapy
Cell Line, Tumor
Dental Pulp
Head and Neck Neoplasms*
Humans
Mesenchymal Stem Cells*
Metal-Organic Frameworks*
Mouth Neoplasms* / drug therapy
Nanoparticles*
Squamous Cell Carcinoma of Head and Neck

Substances

Metal-Organic Frameworks