Relationship between labeling indices of Ki-67 and BrdUrd in human malignant tumors

Cancer. 1988 Sep 1;62(5):989-93. doi: 10.1002/1097-0142(19880901)62:5<989::aid-cncr2820620525>;2-u.


The relationship between labeling indices of Ki-67 reactive antigen expressed by cycling cells and BrdUrd incorporated into S-phase cells was investigated in 20 patients with malignant tumors. Both of the labeling indices varied greatly from patient to patient; the labeling index of Ki-67 ranged from 37.5% to 1.9% with an average value of 16%, and the BrdUrd labeling index ranged from 23.4% to 1.6% with an average of 9.3%. The Ki-67 labeling index was higher than the BrdUrd labeling index. In general, the values of the Ki-67 labeling index were parallel to those of the BrdUrd labeling index, and the relation Y = 1.59X + 1.15 (r = 0.89) was obtained. In human solid tumors, therefore, the growth fraction can be easily estimated from the S-phase fraction size, and vice versa.

MeSH terms

  • Adenocarcinoma / immunology
  • Adenocarcinoma / pathology
  • Antigens / analysis*
  • Bromodeoxyuridine*
  • Carcinoma, Squamous Cell / immunology
  • Carcinoma, Squamous Cell / pathology
  • Cell Division
  • Humans
  • Neoplasms / immunology
  • Neoplasms / pathology*
  • Nuclear Proteins / analysis*


  • Antigens
  • Nuclear Proteins
  • Bromodeoxyuridine