[Metabolic effects of succinic and nicotinic acids in emotional pain stress]

Farmakol Toksikol. 1988 May-Jun;51(3):41-5.
[Article in Russian]

Abstract

In experiments on rats it was shown that administration of succinic and nicotinic acids in doses of 30 and 4 mg/kg for 5 days elevated pyruvic acid level and changed catecholamine balance in tissues of the aorta and heart. The administration of the drugs to rats with current-induced stress partially eliminated unfavourable shifts in carbohydrate metabolism and catecholamine balance in the aortic and cardiac tissues. Succinic acid had more pronounced metabolic activity.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adrenal Glands / drug effects
  • Adrenal Glands / metabolism
  • Animals
  • Aorta / drug effects
  • Aorta / metabolism
  • Drug Evaluation, Preclinical
  • Heart / drug effects
  • Male
  • Myocardium / metabolism
  • Niacin / therapeutic use*
  • Pain / drug therapy*
  • Pain / metabolism
  • Rats
  • Stress, Psychological / drug therapy*
  • Stress, Psychological / metabolism
  • Succinates / therapeutic use*
  • Succinic Acid
  • Time Factors

Substances

  • Succinates
  • Niacin
  • Succinic Acid