Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA

FEBS Lett. 1988 Aug 29;236(2):357-61. doi: 10.1016/0014-5793(88)80055-3.


The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801-810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3'-end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue-specific regulation of this gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Clofibrate / pharmacology
  • Cytochromes / genetics*
  • Gene Expression Regulation
  • Hydrogen Bonding
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • RNA Splicing
  • RNA, Messenger / genetics*
  • Rats


  • Cytochromes
  • RNA, Messenger
  • cytochrome P-452
  • Clofibrate

Associated data

  • GENBANK/X07259