Psilocybin: A brief overview for psychiatric mental health nurse practitioners

Perspect Psychiatr Care. 2022 Jul;58(3):1200-1203. doi: 10.1111/ppc.12888. Epub 2021 Jun 8.


The use of psychedelics, such as psilocybin, has emerged in recent literature as a novel therapeutic treatment for various psychiatric disorders, including substance use, depression, and anxiety. While international and domestic trials are currently underway, there is data demonstrating both the relative safety and potential efficacy of psilocybin. Psychiatric mental health nurse practitioners are essential mental health providers that may be at the forefront of delivering these new treatment modalities. Therefore, they must be aware of the psychopharmacological and psychotherapeutic tenets of psilocybin to be prepared to treat patients.

Keywords: PMHNPs; hallucinogenic; psilocybin; psilocybin in psychiatry; psychiatric care.

MeSH terms

  • Hallucinogens* / pharmacology
  • Hallucinogens* / therapeutic use
  • Humans
  • Mental Health
  • Nurse Practitioners*
  • Psilocybin / pharmacology
  • Psilocybin / therapeutic use
  • Substance-Related Disorders*


  • Hallucinogens
  • Psilocybin